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(3) Condensation of the tail and head group: Once both the benzoquinone head group precursor (4-HB) and the isoprenoid side chain (polyprenyl pyrophosphate, PPP) are synthesized, the enzyme COQ2 catalyzes their condensation via an electrophilic aromatic substitution 33

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These layers function in dynamic equilibrium, and disruption of any component can initiate intestinal immune inflammation

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